The beginnings of this road are in Rome at the Porta San Sebastiano. You can get there via bus (lines 218 and 760), car, or taxi. Be careful though, as car traffic is highly limited at certain parts of the road. I’d really suggest visiting because it’s in great condition and lets you see how Roman roads were thousands of years ago. In its day, the road connected Rome with other ancient cities to the east in Italy. It was built in 312BC and reached the doors of Benevento, Taranto, and Brindisi.
There are some interesting sights along the way. As you start walking from the Porta San Sebastiano, you'll see a place to rent bikes. I'd suggest getting there early because it fills up fast and the chance to explore this ancient road by bike is an experience worth trying. The first thing you'll find is the Church of Domine Quo Vadis, where, according to legend, Jesus uttered those fateful words to Peter as he fled Rome. Inside the church, there is a spot where Jesus' feet are supposedly engraved into the marble. The Catacombs of San Callixtus and San Sebastiano are further down and merit visits of their own.
There, you reach an area of tombs. One of the most recognizable is that of Cecilia Metella which is shaped like a giant barrel. This is the final point that can be reached by car. The rest of the road is a mixture of rolling hills, cypress trees, and amazing views. That's the time to just close your eyes and ponder the stones underfoot which were placed there over 2,000 years ago.
If you are lucky enough to visit Rome and you have time to choose where to stay, I suggest these streets: Via Firenze and Via Nazionale. It's a great area to stay in Rome, as it is very close to all the major sights. In Via Firenze between Via Nazionale and Via Modena there are plenty of Bed and Breakfasts located on different floors of the many old houses on the block. I stayed at Notti a Roma. Prices are good. There are many places to sit and drink or eat nearby.
If you aren't tired of walking and you've decided to visit the Trevi Fountain, it's a great experience because of the buildings and since it is diagonal you'll quickly arrive at the much-talked-about fountain. Be sure to look at the buildings, gates, lanterns and why not look the modern vehicles the Romans are driving; The SMART cars are so small, expensive, and easy to park as you'll see in the photos attached.
In Rome, on Via San Paolo della Croce (St. Paul of the Cross) is the Basilica of Santa Maria in Domnica and the "Navicella". In front of the church is the fountain called "Navicella", this fountain was built under Pope Leo X in the early 1500s, and is named after the small boat in the midst. It is believed that the "Navicella" is a vow to the Goddess Isis, protector of sailors, in gratitude for the salvation of a shipwreck.
If you want to get lost in Rome, this is the place for it. It is a narrow street with interesting shops, far from the sprawling and crowded parts of the city. It takes you from around the Vatican to Piazza Navona and is like going through a tunnel from one environment to another.